Regulation of gene expression in the preimplantation mouse embryo: Temporal and spatial patterns of expression of the transcription factor Sp1

1997 ◽  
Vol 46 (3) ◽  
pp. 268-277 ◽  
Author(s):  
Diane M. Worrad ◽  
Richard M. Schultz
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Spatial Patterns ◽  
Mouse Embryo ◽  
Regulation Of Gene Expression ◽  
Temporal And Spatial Patterns ◽  
Transcription Factor Sp1 ◽  
Preimplantation Mouse Embryo ◽  
Preimplantation Mouse ◽  
Temporal And Spatial

Regulation of gene expression in the preimplantation mouse embryo

1995 ◽  
Vol 44 (8) ◽  
pp. 1115-1131 ◽  
Author(s):  
R.M. Schultz ◽  
D.M. Worrad ◽  
W. Davis ◽  
P.A. De Sousa
Keyword(s):  
Gene Expression ◽  
Mouse Embryo ◽  
Regulation Of Gene Expression ◽  
Preimplantation Mouse Embryo ◽  
Preimplantation Mouse

Temporal and spatial patterns of the synthesis of tissue-specific polypeptides in the preimplantation mouse embryo

Development ◽  
1978 ◽  
Vol 44 (1) ◽  
pp. 191-199
Author(s):  
A. H. Handyside ◽  
M. H. Johnson
Keyword(s):  
Developmental Period ◽  
Mouse Embryos ◽  
Individual Species ◽  
Temporal And Spatial Patterns ◽  
Preimplantation Mouse Embryo ◽  
Polypeptide Synthesis ◽  
Preimplantation Mouse ◽  
Temporal And Spatial ◽  
Qualitative Pattern ◽  
The Individual

Mouse embryos at different morphological stages in the transition from morula to blastocyst were analysed for the qualitative pattern of their polypeptide synthesis. The firstappearance of the individual species of polypeptides specific to trophectoderm or ICM occurred progressively over this developmental period. Populations of inside cells recoveredfrom morulae and early blastocysts synthesized those polypeptides previously shown to be characteristic of ICMs at 3½ days, but not those characteristic of trophectoderm.

scholarly journals The Dynamic DNA Demethylation during Postnatal Neuronal Development and Neural Stem Cell Differentiation

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Huikang Tao ◽  
Pei Xie ◽  
Yuhang Cao ◽  
Liqi Shu ◽  
Liping Li ◽  
...  
Keyword(s):  
Gene Expression ◽  
Spatial Patterns ◽  
Neuronal Development ◽  
Stem Cell Differentiation ◽  
Brain Regions ◽  
Dna Demethylation ◽  
Dynamic Features ◽  
Dot Blot ◽  
Temporal And Spatial Patterns ◽  
Temporal And Spatial

Background. DNA demethylation, the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC), plays important roles in diverse biological processes and multiple diseases by regulating gene expression. Methods. In this study, utilizing DNA dot blot, immunofluorescence staining, and qRT-PCR, we studied the expression pattern of Tets, the enzymes governing DNA demethylation, and the levels of 5hmC, 5fC, and 5caC during the postnatal neuronal development of mice. Results. It was found that 5hmC, 5fC, and 5caC were highly enriched in multiple brain regions and aNSCs and displayed temporal and spatial patterns during postnatal neuronal development and the differentiation of aNSCs. Consistently, the expression of Tets also exhibited temporal and spatial patterns. Conclusion. DNA demethylation displayed dynamic features during postnatal neuronal development and the differentiation of aNSCs of mice, which could contribute to appropriate gene expression.

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